Collagenase Clostridium histolyticum : emerging practice patterns and treatment advances

OBJECTIVE This study aims to provide a comprehensive review of the role of Collagenase Clostridium histolyticum (CCH). METHODS This review is based on a literature review and practical experience. RESULTS This review provides practical management strategies for using collagenase by sharing clinical experiences over the past few years; logistical aspects of in-clinic treatment, lessons learned, and novel approaches to correct traditionally hard-to-treat contractures are discussed. In addition a brief, yet comprehensive overview is provided on the pathophysiology of the disease, the mechanism of collagenase action and results of clinical studies. CONCLUSION CCH has an evolving role as one of the tools available for treating Dupuytren's disease.